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» Background

The discovery of antibiotics and their widespread availability revolutionised healthcare after the Second World War. They underpin many of the greatest medical advances of the 20th century. But bacteria and pathogens have always evolved to resist the new drugs that scientists invent to combat them. Resistance has increasingly become a problem in recent years because the pace at which we are discovering new antibiotics has slowed drastically, while antibiotic use, and therefore resistance, is rising.

Antimicrobial resistance is a natural process whereby microbes evolve to be able to resist the action of drugs, making them ineffective. Resistance arises from the selection pressure that antimicrobials put on populations of microbes; essentially selecting or allowing those microbes to survive and proliferate, typically through genetic changes. This leads to antibiotics becoming less effective over time and in many extreme cases, ultimately useless.

Although AMR is a naturally occurring process, today it is a threat because of two main reasons. The first is that use of antimicrobials has increased so much in the last few decades that microbes are exposed to a much larger number and greater concentration of antimicrobials increasing their chances of developing resistance. The second is that, worryingly, in some categories of antimicrobials (particularly antibiotics) there are very limited numbers of new drugs under development to replace those rendered ineffective by rising drug resistance. Essentially, the demand for new drugs has increased due to increasing resistance but the supply has dried up leaving us in a precarious position.

The reasons for this problem are at least partly economic and commercial. In the case of antibiotics, the predominance of cheap generics means that prevailing prices are low; unpredictable patterns of emerging resistance make future medical needs (and thus commercial opportunities) hard to predict ; and conservation measures necessary to limit the prescribing of antibiotics would relegate new products to last-line treatments used only when nothing else works. This all leads to antibiotics being seen as commercially unattractive. Economic interventions are thus needed to stimulate investment whilst protecting drugs from unnecessary use.

The global burden of infections resistant to existing antimicrobial medicines is now growing at an alarming pace. Drug-resistant infections are already responsible for more than half a million deaths globally each year. Early research commissioned by the Review suggests that if the world fails to act to control resistance, this toll will exceed 10 million each year by 2050 and have cost the world over 100 trillion USD in lost output.

Resistance is not an isolated phenomenon though the extent of resistance varies across different countries and regions of the world. This variation is often linked to the extent of use in these countries or regions. For instance areas with greater use of antimicrobials are associated with greater levels of resistance. But increasing international travel means that AMR has the capability of spreading globally including to countries that are controlling their antibiotics use effectively. This makes a strong case for international coordination on AMR as no country can protect itself from resistant bacteria unless the world takes action together.

Added to these issues, are the overuse and unnecessary use of antimicrobials for humans and animals which also promote the development and spread of resistance, either directly or through the environment.

Much of the misuse of antimicrobials is associated with the lack of rapid diagnostics that can pin-point the exact nature of the diseases causing microbe. Doctors and prescribers, unsure of the kind of disease affecting their human or animal patient but still needing to provide treatment to them, rely on empirical or treatment with broad-spectrum drugs that may or may not cure the patient but still expose microbes to a variety of drugs increasing the likelihood of resistance developing of these drugs.

Figures suggest that much of the use of antibiotics in the world is for animals rather than humans and that much of this is for promoting the growth of animals rather than treating sick animals. The development and spread of drug resistance in the environment is also often overlooked. Antimicrobials can also reach the environment through waste products from the manufacturing sector that do not adequately treat the waste products and through use and excretion by humans and animals.

The overuse of antimicrobials is also related to high rates of infection and the dependence on antimicrobials as curative treatments, reducing the focus afforded to prudent measures that might prevent an infection in the first place.

AMR is an issue that spans multiple areas and cannot be solved by any one solution. Nor is it an issue that any one country can address successfully by acting alone. Hence a multi-disciplined approach to solving the diverse issues and coordination among various countries is critical.

“By highlighting the vast financial and human costs that unchecked drug resistance will have, this important research underlines that this is not just a medical problem, but an economic and social one too.”- Dr Jeremy Farrar, Director of the Wellcome Trust

~ Hockey for Fans and Players of Color

14 Monday May 2018

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Like any good journalist, Irene Schmidt-Adeney loves to unravel a good mystery.

Irene Schmidt-Adeney

But Schmidt-Adney, a reporter for the Ayr News, a weekly publication in Southwestern Ontario, Canada, didn’t realize how deep she would have to dig to try to solve the mystery of Henry Elmer “Buddy” Maracle .

Ayr News, Henry Elmer “Buddy” Maracle

Henry Maracle, standing, with the N.Y. Rangers in 1930-31.

She wondered why hockey history hasn’t shown love to Maracle, an Ayr product who appears to have been the first indigenous player in the National Hockey League .

National Hockey League

Maracle, a Mohawk from Six Nations , played 11 regular season games and four Stanley Cup Playoffs contests for the New York Rangers in 1930-31. He tallied a goal and 3 assists in his short tenure with the Blue Shirts.

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Hockey historians regard Fred Sasakamoose as the first NHL’s first indigenous player with Mens Nike SB Check Solarsoft Canvas Premium Skateboarding Shoe 45r1aq
.Sasakamoose, a member of theAhtahkakoop Cree Nation, played 11 games for the Chicago Blackhawks in 1953-54 without registering a point.

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Reporter Irene Schmidt-Adeney holds a jersey provided by the New York Rangers with Henry Maracle’s name and number on the back (Photo/Courtesy Irene Schmidt-Adeney/Ayr News).

Sasakamoose is also a member of the Saskatchewan First Nations Sports Hall of Fame. the Saskatchewan Sports Hall of Fame, the Prince Albert Hall of Fame and the Canadian Native Hockey Hall of Fame.

“It’s great that he got the Order of Canada, but Maracle should be recognized,” said Schmidt-Adeney, who published her story about Maracle in March after months of exhaustive research. “We’re not going to go out and demand that the Order of Canada come off Fred’s neck. It would just be nice if Henry Maracle was recognized.”

Sgt. Joshua Long, an automated logistics specialist with the Whitewater, Wisconsin-based Company A, 257th Brigade Support Battalion, and fellow competitor, explained that the variety of events can be difficult to prepare for, but it is part of what Soldiers are trained to do.“You have to prepare for everything and be ready for everything, said Long. “It’s the whole concept of the expeditionary force. “You have to be ready to do anything at any time.”1st Sgt. Anthony Coman, the senior non-commissioned officer with the 173rd Brigade Engineer Battalion, 32nd Infantry Brigade Combat Team, said competitors bring back a wealth of knowledge and experience from the competition and share it with their peers. “The units sacrifice time with their most skilled Soldiers to send them to the competition but it’s well worth the cost,” Coman said. Conde believes the mere act of completing the tasks in 52 hours is an achievement. “This competition takes people who thought they could be the best and makes them the best,” said Conde. “They are tired but they have accomplished something in their military career. That sense of accomplishment will carry the competitors for a very long time.”The skills and challenges represented in the crucible of the Best Warrior Competition serve as examples of the sorts of challenges Wisconsin Army National Guard Soldiers overcome as they fulfill their mission for the American people and the State of Wisconsin. The Guard serves as both the state’s first military responder in times of emergency and as the primary combat reserve of the Army.Best Warrior competitors included:32nd Infantry Brigade Combat Team: Spc. Erick Guzman, Company B, 173rd Brigade Engineer Battalion (Onalaska); Spc. Austen Jahnke, Company A, 1st Battalion, 128th Infantry (Menomonie); Sgt. Clayton Smith, Detachment 1, Headquarters Battery, 1st Battalion, 120th Field Artillery (Berlin); Sgt. Daniel Sward, Troop A, 1st Squadron, 105th Cavalry (Fort Atkinson); Spc. Jason Wagner, Detachment 1, Headquarters Battery, 1st Battalion, 120th Field Artillery (Berlin).64th Troop Command: Spc. Colton Babb, 107th Forward Support Company (Sparta); Sgt. David Kittel, 1158th Transportation Company (Beloit); Spc. Michael Spielvogel, 1157th Transportation Company (Oskhosh); Spc. Blake Stoss, Company D, 1st Battalion, 147th Aviation (Madison).157th Maneuver Enhancement Brigade: Sgt. Jonathan Hitchcock, Detachment 1, 829th Engineer Company, 724th Engineer Battalion (Richland Center); Pfc. Michael Kral, Headquarters Company, 157th MEB (Milwaukee); Sgt. Joshua Long, Company A, 257th Brigade Support Battalion (Whitewater); Spc. Marguerite Zaepfel, Company A, 257th Brigade Support Battalion (Whitewater).426th Regional Training Institute/Wisconsin Recruiting and Retention Battalion: Sgt. Curtis Bluel, Headquarters Detachment, 426th RTI (Fort McCoy). Wisconsin National Guard public affairs Soldiers provided extensive coverage of the competition via Facebook Live videos and with photos posted to our Flickr album. Visit the Wisconsin National Guard Facebook Page and the Wisconsin Department of Military Affairs Flickr page at adidas Superstar W BB0530 Whitegreypink 92sAHv7E
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Coastal Resilience is a global network of practitioners who are applying an approach and web-based mapping tool designed to help communities understand their vulnerability from coastal hazards, reduce their risk and determine the value of nature-based solutions.

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